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Home - Products - GPCR/G Protein - Melanocortin Receptor - MCL 0020

MCL 0020

CAS No. 475498-26-1

MCL 0020( —— )

Catalog No. M22356 CAS No. 475498-26-1

Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MCL 0020
  • Note
    Research use only, not for human use.
  • Brief Description
    Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats.
  • Description
    Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
  • In Vitro
    MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63.
  • In Vivo
    MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice.MCL0020 significantly reverses stress-induced anorexia in rats.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Melanocortin Receptor
  • Recptor
    melanocortin-4 receptor (MC4R)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    475498-26-1
  • Formula Weight
    609.73
  • Molecular Formula
    C34H39N7O4
  • Purity
    >98% (HPLC)
  • Solubility
    25% ethanol / water:2 mg/mL
  • SMILES
    CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID:
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